Kuhn E, et al. - The researchers intended to identify subjective cognitive decline (SCD) groups on the basis of whether or not they were referred to a memory clinic by evaluating factors correlated with increased Alzheimer’s disease (AD) risk. They included 78- cognitively unimpaired older adults from the IMAP+ study, including 28 healthy controls (HC) and 50 SCD patients from the community (n=23) or a memory clinic (n=27). Both SCD groups exhibited comparable cognitive performance vs HC, but greater informant-reported SCD and anxiety. Greater informant-reported SCD, depression score, and atrophy progression over time was seen by the SCD-clinic vs the SCD-community, but comparable brain amyloid load was demonstrated. Higher subclinical depression and informant-reported SCD described the SCD group which referred to a memory clinic. As they exhibited greater atrophy progression over time, the same group seemed like a weaker population vs SCD-community. Nonetheless, both the SCD groups were quite alike otherwise, including for brain amyloid load and the SCD-community presented higher depression score over time. Collectively, the significance of evaluating psychoaffective factors and informant-reported SCD in SCD populations and point to both differences and likenesses in SCD populations referring to or not to a memory clinic was demonstrated in this study.