Cao R, et al. - Researchers examined the association between probable rapid eye movement (REM) sleep behavior disorder (pRBD) and impulse control disorders (ICDs) in drug-naïve patients with Parkinson disease (PD). Further, they assessed if baseline pRBD is linked with a higher incidence of ICDs during follow-up. The Parkinson's Progression Markers Initiative (PPMI), an international, multicenter, prospective cohort study, was undertaken to recognize biomarkers of PD progression. Inclusion of 423 drug-naïve patients with early-stage PD was done in the cross-sectional analysis, and a longitudinal analysis was conducted on 320 patients who screened negative for any ICDs or related behaviors at baseline. The longitudinal analysis revealed the independent predictive value of baseline pRBD for ICD development over time. Younger age-of-onset and greater STAI state score were the other significant predictors of ICDs. Findings support recognizing baseline pRBD in early-stage PD for adopting a better therapeutic strategy so as to prevent or limit neuropsychiatric complications.