Mazzoni A, et al. - In this present study, the authors aimed to assess the ability of a 1-ethyl-3 (3-dimethylaminopropyl) carbodiimide (EDC)-containing primer to improve immediate bond strength of either self-etch or etch-and-rinse adhesive systems and to stabilize the adhesive interfaces over time. In addition, they examined the effect of EDC on the dentinal MMPs activity using zymographic analysis. The efficacy of EDC over time was supported by μTBS and zymography results. Findings showed that changes within the dentin matrix promoted by EDC were not adhesive-system-dependent.