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CPAP adherence, mortality, and progression-free survival in interstitial lung disease and OSA

Chest Jul 20, 2020

Adegunsoye A, Neborak JM, Zhu D, et al. - This 10-year retrospective observational multicenter cohort study is done to investigate if CPAP therapy is related to long-term clinical results among patients experiencing coexistent OSA and interstitial lung disease (ILD). Experts hypothesized that reduced death and improved progression-free survival (PFS) are related to adherence to CPAP therapy in patients with ILD with OSA. Participants were grouped, on the basis of OSA severity, into no/mild OSA (apnea-hypopnea index score < 15) or moderate/severe OSA (apnea-hypopnea index score ≥ 15). Inclusion criteria were fulfilled by 160 patients, of those, 131 encountered OSA and were prescribed CPAP. There was no link between adherence to CPAP and improvement in all-cause death risk or PFS, vs those that were nonadherent or untreated. Overall, findings revealed no link of OSA severity or adherence to CPAP with improved results in patients suffering from ILD except those needing supplemental oxygen.

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