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COVID‐19–associated pulmonary aspergillosis: A prospective single‐center dual case series

Mycoses Feb 20, 2021

Meijer EFJ, Dofferhoff ASM, Hoiting O, et al. - Given the emergence of COVID‐19–associated pulmonary aspergillosis (CAPA) as an invasive fungal disease, which often affected previously immunocompetent, mechanically ventilated, intensive care unit (ICU) patients, researchers sought to report a single‐center prospective case series with CAPA cases from both the first (March‐May, n = 5/33) and second (mid‐September through mid‐December, n = 8/33) COVID‐19 wave at a 500‐bed teaching hospital in the Netherlands. In this series, CAPA was diagnosed in 19.7% (n = 13/66) of mechanically ventilated SARS‐CoV‐2 patients. In the second wave, a significant reduction was observed in COVID‐19 patients requiring mechanical ventilation on the ICU. As the numbers are too small, no evaluation can be done whether there exist a true difference in CAPA incidence in mechanically ventilated patients between the two waves, and whether it could be attributed to dexamethasone SARS‐CoV‐2 therapy.

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