Zhang S, Akmar LZ, Bailey F, et al. - Given a major causative role of respiratory syncytial virus (RSV) in acute lower respiratory infection (ALRI) in young children aged < 5 years, researchers sought to determine the global inpatient and outpatient cost of management of RSV-ALRI in young children in order to aid health policy makers in taking decisions concerning resource allocation for interventions to decrease severe morbidity and mortality from RSV in this age group. Searching 3 electronic databases including Global Health, Medline, and EMBASE, they identified 41 studies yielding data from year 1987 to 2017, mainly from Europe, North America, and Australia. These studies covered the management of a total of 365,828 RSV disease episodes. Analysis revealed €4160 (95% CI, 3237–5082) increased cost of hospitalization in correlation with known risk factors (early and late preterm birth, congenital heart disease, chronic lung disease, intensive care unit admission, and ventilator use). In young children in 2017, the global cost of inpatient and outpatient RSV ALRI management was about €4.82 billion, 65% of these in developing countries and 55% of global costs accounted for by hospitalization. Findings thereby suggest that a substantial economic burden is imposed by RSV on health systems, governments, and the society.