Cadham CJ, Cao P, Jayasekera J, et al. - This study was intended to compare the advantages and expenses associated with different smoking cessation interventions to help screening programs choose the most appropriate cessation approach. Researchers performed a societal-perspective cost-effectiveness analysis using a Cancer Intervention and Surveillance Modeling Network model simulating individuals born in 1960 over their lifetimes. They classified model inputs into Medicare, national cancer registries, published studies, and micro-costing of cessation interventions. All cessation interventions decreased cases of and deaths from lung cancer vs screening alone. Costs per quality-adjusted life-years saved seen with cessation were well below accepted willingness to pay thresholds, even with the lowest intervention effects. Benefits with reasonable costs were seen with all smoking cessation interventions delivered with lung cancer screening. The choice of intervention should be governed by practical concerns such as staff training and availability, since the variations between approaches were small.