LeBrun DG, DeFrancesco CJ, Fabricant PD, et al. - This is was undertaken to investigate the cost-effectiveness of a trial of nonoperative management vs early drilling in the treatment of skeletally immature patients with stable osteochondritis dissecans (OCD) of the knee. Researchers applied a decision tree model to compare the cost-effectiveness of a trial of nonoperative management vs early drilling (within 6 weeks of the first office visit) from the payer and societal perspectives over a 3-year time horizon. They derived the relevant transition probabilities, costs (in 2019 US dollars based on Medicare reimbursement), health state utilities, and times to healing from the literature. The outcomes imply that early drilling may be cost-effective from both payer and societal perspectives, although the traditional approach to stable OCD lesions of the knee in skeletally immature patients has been a trial of nonoperative management.