Gouider D, Khallouli A, Maalej A, et al. - Researchers performed a prospective double-blind randomized study to compare tolerance and efficiency between topical 0.5% cyclosporine A (CSA) and fluorometholone (FML) for subepithelial infiltrates (SEI) complicating epidemic keratoconjunctivitis. Seventy-two eyes {38 eyes treated with topical FML (FML group) and 34 eyes with CSA 0.5% eye drops (CSA group)} with SEI were analyzed. Tolerance was assessed by Schirmer test value, burning on eye drops instillation, and conjunctival injection. Both groups had identical baseline characteristics. Both FML and CSA will favourably evolve epidemic keratoconjunctivitis. FML has a quicker impact, and CSA is more long-lasting with less recurrences. Both are effective long-term treatment options for SEI. There was no evidence of ocular hypertension.