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Corticosteroids added to initial intravenous immunoglobulin treatment for the prevention of coronary artery abnormalities in high‐risk patients with Kawasaki disease

Journal of the American Heart Association Sep 04, 2020

Ae R, Abrams JY, Maddox RA, et al. - By examining large‐scale data from nationwide Kawasaki disease (KD) surveys in Japan, researchers investigated whether addition of corticosteroids to initial intravenous immunoglobulin treatment affords a superior prophylactic against the development of coronary artery abnormalities in patients with KD. They compared standard intravenous immunoglobulin treatment and combination treatment. According to findings, the risk of coronary artery abnormality was attenuated by an estimated 47% and treatment failure was reduced by 35% among patients who received combination treatment. In selected patients at high risk for KD, multiple‐dose corticosteroids may be beneficial.

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