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Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations

Bipolar Disorders May 21, 2018

Mørch-Johnsen L, et al. - Morphometric correlates of auditory hallucinations in bipolar disorder (BD) were investigated by comparing cortical thickness and cortical surface area in bipolar disorder patients with (BD+) and without (BD-) a lifetime history of auditory hallucinations. Bipolar disorder spectrum patients and healthy controls underwent 1.5T magnetic resonance imaging (MRI) scanning and were analyzed for cortical thickness and surface area in regions of the auditory cortex (Heschl's gyrus [HG], planum temporale and superior temporal gyrus) comparing BD+ and BD- using linear regression models, covaried for age and sex. Findings suggested cortical thickness alterations in both the left HG and the superior parietal lobule were associated with a lifetime history of auditory hallucinations in BD. BD+ showed thicker cortex compared to BD-.

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