Andreasson AC, et al. - In this study performed on drug-naïve patients, with new-onset epilepsy recruited from the Queen Silvia's Children's Hospital, Gothenburg, Sweden, researchers assessed cortical excitability with transcranial magnetic stimulation (TMS) prior to as well as following antiepileptic drugs (AEDs) in 48 children, including 23 females and 25 males (mean [SD] age 10y [3y], range 4–15y), with epilepsy (27 generalized and 21 focal). Findings revealed a reduction in cortical excitability as measured with resting motor threshold following the introduction of AEDs. This was identified in pediatric cases with both generalized and focal epilepsy managed with sodium valproate, although it was found to be most prominent in pediatric patients suffering from generalized epilepsy. It was indicated that TMS might serve as a prognostic instrument to foretell AED efficacy.