Agarwal R, Sen S, Kashyap S, et al. - In this prospective interventional study involving 66 eyes of 39 primary congenital glaucoma (PCG) children aged ≤ 12 months at diagnosis, researchers sought to correlate histopathological changes of trabecular meshwork with clinical features in PCG. Corneal clarity, corneal diameter, intraocular pressure (IOP) and cup disc ratio (C:D ratio) have been evaluated at baseline and at 1-year follow-up. A lower baseline IOP was associated with the presence of an eosinophilic membrane on the cameral surface. At final follow-up, eyes with IOP ≤ 14 mmHg had lower trabecular endothelial cells count than eyes with IOP > 14 mmHg. The prognosis of PCG may be driven by light microscopic analysis of surgical specimens. To confirm these outcomes, however, larger studies are required.