Laban M, Nassar S, Elsayed J, et al. - Researchers conducted a retrospective record-based study at Gynecology Oncology Unit, Ain Shams University Maternity Hospital, Cairo, Egypt with the aim to compare the diagnostic accuracy of preoperative and postoperative endometrial sampling retrieved by dilatation and curettage (D&C), Pipelle and hysteroscopy to endometrial malignancies. In addition, they examined the adequacy of surgical treatment for these patients. Among the three biopsy methods, D&C showed the highest sensitivity of 61.9%; hysteroscopy exhibited 100% specificity, while Pipelle was identified to be the least accurate method. Finally, adequate surgical treatment was identified in 61.4% of the patients. Findings revealed excellent concordance rates between initial biopsy and postoperative pathology in diagnosis of high grade endometrioid and other endometrial malignancies when compared with endometrial hyperplasia and low grade endometrioid adenocarcinoma. More surveillance is recommended in patients diagnosed initially with atrophic endometrium or hyperplasia prior to undertaking their surgical treatment. Based on findings, they emphasize the necessity for developing protocols for improving accuracy of endometrial sampling such as conducting molecular studies for preoperative pathology.