Krumeich LN, Cucchiara AJ, Nathanson KL, et al. - In this retrospective cohort study (1999–2020), researchers sought to assess associations between plasma catecholamines, body weight, and hemoglobin A1C (HA1C). Three hundred sixty patients [median age 59 years (IQR: 45–67) and 56.4% (N=203) were female] were identified prospectively by referral to the center for management or surveillance of pheochromocytomas and paragangliomas (PCC/PGL). Plasma norepinephrine and its metabolite have a direct correlation with HA1C and an inverse correlation with weight in PCC/PGL. Despite an increase in patient body weight, lowering normetanephrine levels associated with better HA1C after resection. MRD is characterized by persistently increased catecholamines and a loss of weight.