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Coronavirus occurrence and transmission over 8 years in the HIVE cohort of households in Michigan

The Journal of Infectious Diseases Apr 08, 2020

Monto AS, DeJonge P, Callear AP, et al. - As part of the Household Influenza Vaccine Evaluation (HIVE) study, children and adults have been examined for acute respiratory infections (ARI) over 8 years. Researchers here tested specimens collected during illness for human coronaviruses (HCoV) types OC43, 229E, HKU1, and NL63. In total, they recognized 993 HCoV infections over 8 years, with OC43 most commonly seen and 229E the least. Detection of HCoVs was observed in a limited time period, between December and April/May; it peaked in January/February. Children < 5 years had the highest infection frequency (18 per 100 person-years); older age groups exhibited a little variation (range: 7 to 11 per 100 person-years). Findings thereby suggest sharp seasonality of coronaviruses. Based on serial interval and secondary infection risk, these viruses seem to have similar transmission potential to influenza A(H3N2) in the same population.

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