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Coronavirus disease 2019 in pregnancy and outcomes among pregnant women and neonates: a literature review

The Pediatric Infectious Disease Journal Apr 20, 2021

Mark E, McAleese S, Golden WC, et al. - In order to determine the outcomes of coronavirus disease 2019 (COVID-19) during pregnancy and risk of vertical transmission in exposed neonates, researchers herein reviewed studies published on this topic from February 1, 2020, through August 15, 2020. As per findings, in the setting of maternal COVID-19, following pregnancy complications were encountered: preterm delivery and fetal distress requiring emergent delivery. In this study, higher rates of cesarean section (57%) and preterm delivery (28%) were observed in pregnancies affected by COVID-19 relative to the general prevalence of cesarean section and preterm birth as reported by the World Health Organization (21% and 11%, respectively). As most reported cases to date have occurred during the third trimester, there were limited data on the effects of maternal infection during early pregnancy. Although, they did not commonly observe vertical transmission from mother to infant, it remains possible based on available reporting. Uncertainty remains concerning the significance of vertical transmission to the newborn. In most newborns who acquire COVID-19, the illness was self-limiting with relatively good clinical outcomes. They emphasize promoting wide participation with the establishment of national and international COVID-19 registries to standardize reporting.

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