Sara JD, et al. - Given that an increased risk of adverse cardiovascular events has been reported in patients with type 2 diabetes mellitus vs those without diabetes, researchers evaluated the link between endothelial-dependent and endothelial-independent coronary microvascular dysfunction and glycemic control in patients presenting with chest pain and nonobstructive coronary disease (stenosis < 40%) at angiography. They estimated the coronary flow reserve ratio in response to adenosine (CFRAdn Ratio) and considered a CFRAdn Ratio ≤ 2.5 as abnormal. In response to intracoronary infusions of acetylcholine, the percentage change in coronary blood flow (%ΔCBFAch) was evaluated, and the definition of microvascular endothelial dysfunction was a %ΔCBFAch of ≤ 50%. Type 2 diabetes was present in 129 of 1,469 patients who had coronary angiography and invasive testing for coronary microvascular dysfunction. Among female diabetics presenting with chest pain and non-obstructive coronary artery disease, a link between poor glycemic control and coronary microvascular dysfunction was observed.