Weber BN, Stevens E, Barrett L, et al. - Researchers sought to investigate if coronary microvascular dysfunction (CMD), defined as abnormal myocardial flow reserve (MFR) by positron emission tomography‐computed tomography, would demonstrate an independent link with systemic lupus erythematosus (SLE) post-adjustment for nonobstructive atherosclerotic burden and common cardiovascular risk factors. A total of 42 consecutive patients suffering from SLE who had symptoms‐prompted stress cardiac positron emission tomography‐computed tomography, were analyzed. CMD was defined as MFR <2. Findings revealed high prevalence of coronary vasomotor abnormalities in SLE cases with cardiac symptoms without obstructive coronary artery disease. A more severe decrease in MFR, that was not accounted for by common cardiovascular factors or atherosclerotic burden, was observed in SLE patients vs symptomatic matched controls.