Miller RJH, et al. - Given that following cardiac transplantation, cardiac allograft vasculopathy (CAV) is an increasingly important complication, researchers assessed whether in patients undergoing coronary computed tomographic angiography (CCTA), quantitative plaque analysis yield additive diagnostic benefit. They identified a total of 36 scans in 17 patients. At a median of 1.9 years prior to CCTA, 17 (46.0%) reference coronary angiograms showed the presence of CAV. Patients with CAV showed higher median non-calcified plaque (NCP) (147 vs 58), low-density NCP (median 4.5 vs 0.9), fibrous plaque (median 76.1 vs 31.1) and fibro-fatty plaque (median 63.6 vs 27.6) volumes; while calcified plaque was not high in these patients (median 0.0 vs 0.0). For CAV, sensitivity of 70.6% and specificity of 100% specific were achieved with visual assessment of CCTA alone. Sensitivity increases to 82.4% with the addition of total NCP volume, while maintaining 100% specificity.