Lo-Kioeng-Shioe MS, et al. - In patients with suspected coronary artery disease, researchers examined the independent links between Agatston score, coronary artery calcium (CAC) volume, CAC area, CAC mass, and CAC density score with major adverse cardiac events. Overall 379 symptomatic subjects (aged 45 to 85 years) who were referred for invasive coronary angiography were included; they also had coronary calcium scanning and computed tomography angiography in the CORE320 (Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Detector Computed Tomography) study. Significant associations of Agatston, volume, and density scores with higher risk of major adverse cardiac events were shown in separate models following adjustment for age, sex, race, and statin use. Among CAC scores, major adverse cardiac events were most strongly and independently predicted by CAC density in symptomatic patients, however, no incremental value of CAC density beyond the Agatston score was seen once the diameter stenosis was adjusted.