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Coronary artery calcium as a synergistic tool for the age‐ and sex‐specific risk of cardiovascular and cancer mortality: the coronary artery calcium consortium

Journal of the American Heart Association Apr 24, 2020

Dzaye O, Al Rifai M, Dardari Z, et al. - This study was attempted to assess whether coronary artery calcium as a synergistic tool for the age‐ and sex‐specific risk of cardiovascular and cancer mortality. Researchers enrolled asymptomatic patients aged 40 to 75 years old without known cardiovascular disease (CVD) from the coronary artery calcium (CAC) Consortium. They estimated sex‐specific mortality rates per 1000 person‐years’ follow‐up. Parametric survival regression modeling was applied to ascertain the age‐ and sex‐specific CAC score at which the risk of death from CVD and cancer were equal. The study population consisted of 59,502 patients, the mean age was 54.9 (±8.5) years, 34% were women, and 89% were white. The data exhibit that for women and men, the age‐ and gender‐specific relationship of CAC with CVD and cancer mortality differed significantly. The age‐ and gender‐specific CAC score serves a more precise calculate and further helps the use of CAC as a synergistic tool in strategies for the prognostication and prevention of CVD and cancer mortality.

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