Wang YH, et al. - In this study of 61 newborns with macrosomia (birth weight ≥4000 g) and 69 newborns with normal birth weight (2500–3999 g), researchers examined the connection between leptin (LEP) methylation in cord blood and non-gestational diabetes mellitus (GDM) macrosomia. In newborns with macrosomia, average levels of cord blood LEP methylation were lower than in newborn controls. Multivariate logistic regression showed that low levels of LEP methylation, high pre-pregnancy body mass index, long gestational age, high cord blood LEP concentration, and male newborn gender significantly raised the risk of macrosomia. According to this case-control study, non-GDM macrosomia was linked to lower cord blood LEP methylation levels and certain maternal and fetal factors.