Neuman RI, van der Meer MMA, Saleh L, et al. - In view of the possible contribution of arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) to the pathogenesis of preeclampsia (PE) and the uncertainty concerning their role, researchers here examined the surrogates of AVP and ANP, C‐terminal pro‐AVP (copeptin) and mid‐regional pro‐ANP (MR‐proANP), as biomarkers for the prediction of PE‐related pregnancy complications and investigated if they are linked with angiogenic markers and/or clinical manifestations of PE. They performed a retrospective analysis of a prospective cohort study evaluating a total of 526 women with suspected or confirmed PE. Serum copeptin and MR‐proANP levels were higher in women with confirmed PE vs those with suspected PE but no hypertensive disease of pregnancy. Overall findings suggest limited value of copeptin and MR‐proANP in predicting PE‐related complications when compared with the sFlt‐1/PlGF ratio. Both copeptin and MR‐proANP, however, were linked with proteinuria, with copeptin exerting this effect independently of the sFlt‐1/PlGF ratio.