Tran DT, Le MT, Chuang L, et al. - This prospective cohort study with data from 475 patients was conducted to assess the Copenhagen Index (CPH-I) and Risk of Ovarian Malignancy Algorithm (ROMA) diagnostic performances in the preoperative prediction of ovarian cancer. There were 475 females, 408 had benign tumors, 5 had borderline tumors and 62 had malignant tumors. For ovarian cancer diagnosis, ROMA and CPH-I offered sensitivities/specificities of 74.2% and 91.8%, 87.1% and 78.5%, respectively, at an optimal cut-off. The optimal cut-off for CPH-I was noted to be 1.89%. Overall, the Copenhagen Index might be used as a simple alternative with a similar efficacy to ROMA for clinically stratifying the malignancy risk of ovarian tumors regardless of menopausal status.