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Copd as an independent risk factor for osteoporosis and fractures

Osteoporosis International Mar 21, 2020

Adas-Okuma MG, Maeda SS, Gazzotti MR, et al. - A case-control study was performed to evaluate the prevalence of osteopenia, osteoporosis, and fractures in patients with chronic obstructive pulmonary disease (COPD), and distinguished potential risk factors for fractures in this population. Researchers investigated a total of 91 individuals with COPD (COPD group; COPDG) and 81 age- and gender-matched controls (control group; CG) with bone mineral density (BMD), thoracic/lumbar spine radiographs, and serum PTH and 25-hydroxyvitamin D (25[OH]D) levels. In COPD, these outcomes add robust evidence to an increased odds of osteoporosis and fractures. The study found fractures in the COPDG at higher BMD values than expected, implying that COPD may be an independent marker of fracture risk, reinforcing a requirement for regular osteoporosis screening with BMD assessment and prophylaxis of fractures in individuals with this disorder.

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