Ewongwo A, Hamidi M, Alattar Z, et al. - Patient factors contributing to increased incidence of early-onset rectal cancer were investigated and the short-term surgical outcomes of patients undergoing surgery were analyzed. Patients with rectal cancer who underwent surgical management were assessed via performing a 2-year review (2015–2016) of the ACS-NSQIP and were stratified into early-onset RC (< 50-years) and late-onset RC (≥ 50-years). Researchers analyzed a total of 7,538 patients; of these, 14% had early-onset RC. This suggests that one in seven patients < 50 years has early-onset rectal cancer (RC). They identified a unique set of patient-related factors that determine the risk profile. Early onset RC patients were more frequently Black and Hispanic and were also more likely to have disseminated cancer. Aggressive tumors were more frequently observed among early-onset RC patients. However, the two groups exhibited comparable surgical outcomes.