Takeuchi Y, Mabe K, Shimodate Y, et al. - Via a multicenter, parallel, noninferiority randomized, controlled trial conducted at 30 Japanese institutions and involving 184 patients who received anticoagulant therapy (warfarin or direct oral anticoagulants) and who had at least 1 nonpedunculated sub-centimeter colorectal polyp, researchers contrasted outcomes between continuous administration of anticoagulants (CA) with cold snare polypectomy (CSP; CA + CSP) and periprocedural heparin bridging (HB) with hot snare polypectomy (HSP; HB + HSP) for sub-centimeter colorectal polyps. In the HB + HSP and CA + CSP groups, the incidence of polypectomy-related major bleeding was 12.0% and 4.7%, respectively. The intergroup variation for the primary endpoint was +7.3%, with a 0.4% lower limit of 2-sided 90% CI, showing the noninferiority of CA + CSP. For each polyp, the mean procedure time and the hospitalization period were longer in the HB + HSP vs CA + CSP group. In all, patients having CA + CSP for sub-centimeter colorectal polyps who were receiving oral anticoagulants did not demonstrate a greater incidence of polypectomy-related major bleeding, and procedure time and hospitalization were shorter than in those who had HB + HSP.