Breedvelt JJF, Warren FC, Segal Z, et al. - This meta-analysis implies that regardless of the clinical factors included in these studies, during and/or after tapering, the sequential delivery of a psychological intervention may be an effective relapse prevention strategy instead of long-term use of antidepressants. These outcomes could be applied to inform shared decision-making in clinical practice.

• Researchers enrolled a total of 714 participants (mean [SD] age, 49.2 [11.5] years; 522 [73.1%] female) from 4 RCTs that compared preventive cognitive therapy or mindfulness-based cognitive therapy during and/or after antidepressant tapering vs antidepressant monotherapy.

• In this two-stage random-effects meta-analysis, there was no significant difference in time to depressive relapse between use of a psychological intervention during tapering of antidepressant medication vs antidepressant therapy alone (hazard ratio [HR], 0.86; 95% CI, 0.60-1.23).

• It was shown that younger age at onset (HR, 0.98; 95% CI, 0.97-0.99), shorter duration of remission (HR, 0.99; 95% CI, 0.98-1.00), and higher levels of residual depressive symptoms at baseline (HR, 1.07; 95% CI, 1.04-1.10) were correlated with a higher overall risk of relapse.

• The results showed that none of the included moderators were correlated with the risk of relapse.