Go AS, et al. - In a large community-based cohort of adults with chronic kidney disease (CKD), identified via a large integrated healthcare delivery system in northern California, researchers investigated the predictors of quick progression during the first 2 years of follow-up in the presence or absence of diabetes mellitus. Study participants had an estimated glomerular filtration rate (eGFR) 30–59 ml/min/1.73 m², no previous dialysis or renal transplant, outpatient serum creatinine values spaced 10-14 months apart, and did not initiate renal replacement therapy, die or disenroll during the first 2 years of follow-up. They found that within 2 years, around 1 in 4 patients with diabetes and around 1 in 7 without diabetes had accelerated progression of kidney dysfunction. Proteinuria, elevated systolic blood pressure, heart failure and anemia were identified as the strongest independent predictors of fast CKD progression, irrespective of diabetes status.