Roberts G, Fontanella S, Selby A, et al. - Given a link of allergic sensitization with severe asthma but the evaluation of sensitization is not advised by most guidelines, so, researchers investigated whether the patterns of IgE (Immunoglobulin E) responses to multiple allergenic proteins vary between sensitized individuals with mild/moderate and severe asthma. From U-BIOPRED (Unbiased BIOmarkers for the PREDiction of respiratory diseases outcomes) cohort, they analyzed 509 adults, 140 school-age and 131 pre-school children suffering from asthma/wheeze, to obtain measurements of IgE to 112 allergenic molecules (component specific IgE) by employing multiplex array. Using clustering methods, they assessed co-occurrence patterns of components (component clusters) as well as the patterns of sensitization in participants (sensitization clusters). Experts found 4 sensitization clusters, without difference between disease severity groups. They noted higher connectivity among components in participants suffering from severe asthma, although these connections were weaker. Fewer but stronger connections were reported for the mild/moderate network. Findings revealed that asthma severity in school-children and adults with allergic asthma was predicted by the patterns of interactions between IgE to multiple allergenic proteins.