Aryan Z, et al. - This study was designed to elucidate the correlations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D). It was considered that ApoA1 but not HDL-C is straightly correlated with diabetic neuropathy. Even Slight rise in serum Lp(a) is associated with increased frequency of diabetic retinopathLipid variables could serve as specific predictors of vascular complications in diabetes.

Methods

• Researchers performed a nested case-control study within an ongoing prospective study on patients with T2D.
• They evaluated microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy.
• They recruited a sum of 444 cases with at least one of the microvascular complications of T2D and 439 age- and gender-matched controls free of any of the chronic microvascular complications of T2D.
• The correlations and interactions of a panel of serum lipid biomarkers with the microvascular complications of T2D were investigated.

Results

• The evidence showed that serum triglyceride had the strongest correlation with microvascular complications of T2D (crude model: β = 0.632, P value = 0.045).
• In this study, each standard deviation increment in serum TG was correlated with 3.7 times increased frequency of microvascular complications.
• Despite high density lipoprotein cholesterol (HDL-C), they found that serum apolipoprotein A1 (Apo A1) was positively correlated with the presence of diabetic neuropathy.
• They noted that each standard deviation increment in serum ApoA1 was correlated with increased frequency of diabetic neuropathy (OR,1.2, 95%CI,(1.1-1.3), P value = 0.006).
• It was showed that the prevalence of diabetic neuropathy was higher in 2nd and 3rd quartiles of serum Lp(a) compared to diabetic patients in the first quartile (OR, 5.52, 95% (1.17-25.8),P value = 0.047).