Kathryn L. Bacon, et al. - Via the Multicenter Osteoarthritis study, the researchers assessed concurrent variation in quadriceps strength and physical function over 5 years. At 5 years, 22% and 30% of men and women, respectively, rose strength by at least 15% among 1,534 participants. Women whose strength progressed had better chair stand performance yet no improvement in other functions, in comparison with women whose strength did not alter. An increase in strength was not correlated with an important improvement in physical function in men. Comparable outcomes were recognized for a 20% or 30% increase. In conclusion, in women and not in men, moderate betterment in quadriceps strength was correlated with better chair stand performance. Moreover, most functions did not get better with a boost in strength, and targeted interventions may be needed to enhance functional status.