Flores-Guerrero JL, et al. - In a prospective population-based cohort analysis including 4,169 participants from the Prevention of Renal and Vascular End-stage Disease study, researchers investigated the link between branched-chain amino acids (BCAAs) and incident hypertension. They performed nuclear magnetic resonance spectroscopy to obtain measurements of plasma concentrations of BCAAs. They used multivariable-adjusted Cox regression models to estimate the risk of incident hypertension. Participants were observed for a median duration of 8.6 years. Following complete adjustment for various clinical variables, the HR per one SD of BCAAs was estimated to be 1.11 (95% CI: 1.02–1.20). An increased risk of newly developed hypertension was observed in relation to high plasma concentrations of BCAAs. Even after adjusting for age, sex, BMI, and lipid profile, the association persisted.