Rawl SM, Christy SM, Perkins SM, et al. - The effectiveness of two clinic-based interventions for increasing colorectal cancer (CRC) screening were compared among African American primary care patients in this randomized controlled trial. Researchers randomized African American patients not current with CRC screening from 11 clinics to get a computer-tailored intervention (n = 335) or a non-tailored brochure (n = 358) designed to promote adherence to CRC screening. Univariate and multivariable logistic regression models were applied to examine predictors of screening test completion. Multivariable linear and logistic regression analyses were applied to ascertain moderators and mediators. Among low-income African American patients, this one-time computer-tailored intervention significantly improved CRC screening rates. According to the results, increasing stool blood tests was the greatest driver of these results, but the effect of the intervention on colonoscopy screening was robust. The results demonstrated that the implementation of a CRC screening quality improvement program in the VA site that included the provision of stool blood test kits and follow-up likely contributed to the robust intervention effect seen.