Broocks G, Kemmling A, Meyer L, et al. - Via analyzing 176 patients with middle cerebral artery stroke who had mechanical thrombectomy, researchers determined the correlation between collateral status and early lesion water uptake as a quantitative marker for edema progression. The median edema progression rate (EPR) was 1.4% per hour (interquartile range: 0.5% to 3.5%) in patients with good collaterals, which was lower than the median EPR in patients with poor collaterals (5.8% per hour; interquartile range: 2.1% to 5.9%). A higher EPR was linked to a reduced probability of good clinical outcome (defined as modified Rankin Scale score 0 to 2 after 90 days). Patients with poor collaterals had significantly higher EPR, which was associated with worse clinical outcomes. Such patients may benefit from adjuvant antiedematous treatment.