Berwian IM, Wenzel JG, Psych D, et al. - This study was undertaken to ascertain whether the decision to invest effort for rewards represents a persistent depression process after remission, prognosticates relapse after remission, and is affected by antidepressant discontinuation. Between July 1, 2015, and January 31, 2019, researchers performed a longitudinal randomized observational prognostic study (in a Swiss and German university setting collected data, from 66 healthy controls) including individuals with major depressive disorder in response to antidepressants prior to and after discontinuation. This study include a sum of of 123 individuals (mean [SD] age, 34.5 [11.2] years; 94 women [76%]) and 66 healthy controls (mean [SD] age, 34.6 [11.0] years; 49 women [74%]). The outcomes of this study demonstrated that the decision to invest effort was correlated with prospective relapse risk after antidepressant discontinuation and may represent a persistent disease process in asymptomatic remitted major depressive disorder. It was noted that markers based on effort-related decision-making could likely inform clinical decisions correlated with antidepressant discontinuation.