McNeil JC, et al. - Given a frequent association of the Streptococcus anginosus group (SAG, S. anginosus, S. intermedius and S. constellatus) with severe disease and abscess formation has been reported, and in experts' institution, an apparent rise in frequency of intraorbital and intracranial infections resulting from SAG at Texas Children’s Hospital was documented, so, researchers focused on the frequency as well as clinical characteristics of these infections in this retrospective review. For SAG-positive cultures, the database of the microbiology laboratory at Texas Children’s Hospital, from 2011 to 2018, was analyzed. Cases related to either otitis media or sinusitis and Pott’s puffy tumor, orbital abscesses, mastoiditis, epidural abscesses, subdural empyema, brain parenchymal abscesses or dural enhancement by imaging, were included. Most often, S. intermedius was isolated (80%). Staphylococcus aureus was most commonly isolated among polymicrobial cases. Findings revealed substantial morbidity in relation to complications of otitis media and sinusitis induced by SAG. An increasing frequency of occurrence of these infections at the experts' center was reported, although there remains a lack of clarity about the exact reason for this temporal trend.