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Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: A longitudinal study of the Nordic JIA cohort

Pediatric Rheumatology Sep 15, 2019

Glerup M, Thiel S, Rypdal V, et al. - Via conducting a multicenter-based, prospective, observational study of participants from the close to population-based Nordic juvenile idiopathic arthritis (JIA) cohort 17 years after disease onset, researchers aimed to assess the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset. In addition, they sought to correlate the protein levels to markers of disease activity in the participants and to evaluate lectin pathway proteins for their predictive value with respect to remission status. In systemic JIA, they observed the highest level of M-ficolin at baseline which was significantly higher than most of the other categories. Conversely, for the sJIA vs the oligoarticular persistent group showed significantly lower MBL-associated serine protease (MASP)-1 levels. They identified that a high M-ficolin level at baseline and 17-year follow-up was associated with high ESR and on the other hand, high MASP-1 and MASP-3 tended to associate to low ESR. High MASP-1 and MASP-3 were more likely to be associated with low disease activity and CL-K1 was identified to have a negative correlation with juvenile arthritis disease activity score for 71 joints at baseline. Accordingly, it was hypothesized that the high levels of M-ficolin and low levels of MASP-1 and MASP-3 may reflect inflammation in JIA.
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