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Comparison of the associations of early-life factors on wheezing phenotypes in preterm-born children and term-born children

American Journal of Epidemiology Jan 25, 2019

Kotecha SJ, et al. - Researchers examined wheezing phenotypes in preterm-born children as well as investigated if the association of early-life factors and characteristics with wheezing phenotypes was similar between preterm- and term-born children. They examined 1,049/1,502 (70%) preterm-born children and 12,307/17,063 (72%) term-born children from the Millennium Cohort Study who were born between 2000 and 2002 and were studied at 9 months and at 3, 5, 7, and 11 years. They found that phenotypes in preterm-born children were similar to phenotypes in term-born children, 4 wheezing phenotypes defined for both groups were: no/infrequent, early, persistent, and late. In both groups, increased rates for all phenotypes were observed in association with early-life factors and characteristics, especially antenatal maternal smoking, atopy, and male sex. Higher rates of early and persistent wheeze were observed in the preterm-born group. However, the resolve of wheeze with time was seen in a large proportion of preterm-born children who had early wheeze.
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