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Comparison of the association between goal-directed planning and self-reported compulsivity vs obsessive-compulsive disorder diagnosis

JAMA Jan 12, 2020

Gillan CM, Kalanthroff E, Evans M, et al. - Researchers conducted a cross-sectional study, trained rater carried a telephone-based diagnostic interview for individuals with obsessive-compulsive disorder (OCD) and/or generalized anxiety disorder (GAD) from across the United States, from October 8, 2015, to October 1, 2017, in order to investigate whether a self-reported compulsivity dimension has a stronger correlation with goal-directed and related higher-order cognitive deficits contrasted with a diagnosis of OCD. In a total of 285 participants in the analysis, 111 had OCD; 82, GAD; and 92, OCD and GAD. In contrast with GAD at baseline, the diagnosis of OCD was not correlated with goal-directed performance. The compulsivity dimension, however, was negatively correlated with goal-directed performance. It was found that in comparison with OCD diagnosis, deficits in goal-directed planning in OCD might be more robustly correlated with a compulsivity dimension. Finding suggests that research evaluating the correlation in brain mechanisms and clinical manifestations and for understanding the structure of mental illness.
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