• Profile
Close

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women

Menopause Oct 30, 2018

Bhavnani BR, et al. - In an effort to further understand the role of oxidized low-density lipoprotein (LDL) in the etiology of atherosclerosis, researchers investigated the ability of 10 estrogen components of the drug, conjugated equine estrogen (CEE), trans-resveratrol (t-resveratrol) and quercetin (red wine components), trolox (vitamin E analog), and probucol (a serum cholesterol-lowering drug) to delay or prevent the oxidation of plasma LDL isolated from untreated postmenopausal women. They also assessed the effect of long-term (> 1 year) estrogen replacement therapy and hormone replacement therapy on LDL oxidation by ex vivo methods. Various estrogens and other antioxidants differentially inhibited the oxidation of LDL isolated from postmenopausal women. The most potent was the unique ring B unsaturated estrogen components of CEE, and the least potent were t-resveratrol and the red wine component. Long-term CEE or CEE + medroxyprogesterone acetate administration protects the LDL against oxidation to the same extent in postmenopausal women. Data thereby supported that some of the cardioprotective benefits offered by CEE therapy and perhaps red wine may be due to LDL protection against oxidative modifications conferred by their components.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay