Lee Y, Hung CF, Chien CY, et al. - This cross-sectional study was undertaken to compare patients with head and neck cancer (HNC) vs patients with lung cancer (LC) in terms of the prevalence and related factors of depressive disorder. This inquiry was performed in a medical centre (Kaohsiung Chang Gung Memorial Hospital, Taiwan), and the Mini International Neuropsychiatric Interview (MINI) was employed to evaluate the patients. In HNC patients, alcohol use disorder (49.6%) was reported as the most common psychiatric comorbidity, followed by adjustment disorder (20.4%) and depressive disorder (11.5%). In LC patients, depressive disorder (25.0%) was identified as the most common psychiatric comorbidity, followed by adjustment disorder (17.3%), alcohol use disorder (3.8%) and insomnia disorder (3.8%). In HNC patients, a positive correlation of self-harm history with depression, and a negative link of higher educational level with depression, was noted. In LC patients, two significant factors related to depression were severity of stressor and severity of anxiety. In view of these findings, clinicians are advised to be aware of depression as a comorbidity as well as risk factors related to this comorbidity in such patients with cancer, and to perform intervention programmes to avert these cancer patients from experiencing depression.