Henderson J, Bouck J, Holleman R, et al. – Researchers compared changes between the use of two low-value laboratory tests after the release of Choosing Wisely recommendations across three healthcare jurisdictions. They also evaluated changes associated with a related policy change. This cross-sectional study of a population-based interrupted time series included 54,223,448 adults (aged 18-64 years) who had primary care visits between January 1, 2010, and June 30, 2015, or established hypothyroidism between January 1, 2012, and June 30, 2015, across 3 healthcare delivery jurisdictions: Ontario, Canada; the US Veterans Health Administration; and the US employer-sponsored insurance market. In Ontario, Canada, marginal reductions in the use of two low-value laboratory tests were correlated with the release of related Choosing Wisely recommendations, but a greater reduction in low-value vitamin D screening was correlated with a previous payment policy change implemented. Overall, recommendations alone may be insufficient for reducing the use of low-value services, according to findings. However, pairing recommendations with policy changes may be more efficient.