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Comparison of outcomes and prognostic factors between early-stage cervical adenocarcinoma and adenosquamous carcinoma patients after radical surgery and postoperative adjuvant radiotherapy

Cancer Management and Research Oct 07, 2021

Zhou Y, Wang W, Hu K, et al. - Relative to patients with cervical adenosquamous carcinoma (ASC), those with adenocarcinoma (ADC) more frequently exhibited positive pelvic lymph nodes. Patients with ADC and ASC did not exhibit significant differences in survival outcomes.

  • A total of 125 patients (97 with ADC and 28 with ASC) who received radical hysterectomy and postoperative radiotherapy were enrolled.

  • When compared with ASC patients, a higher proportion of positive pelvic lymph nodes were recorded among patients with ADC (7.1% and 26.8%, respectively).

  • The lung was the most common site of distant metastasis, followed by the intestine and colon.

  • ADC and ASC patients had 5-year overall survival (OS) rates of 83.6% and 92.0%, respectively, disease-free survival (DFS) rates of 77.5% and 87.7%, respectively, pelvic control rates of 81.8% and 96.2%, respectively, and distant control rates of 88.3% and 87.7%, respectively.

  • Findings suggest a prognostic value of parametrial invasion for OS and of lymphovascular space involvement for DFS.

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