Maranzano J, et al. - Through multicontrast 3T and 7T MR images from 10 people with relapsing-remitting multiple sclerosis (MS) and 10 with secondary-progressive MS, the researchers contrasted multicontrast cortical lesion detection using 3T and 7T MR imaging, compared cortical lesion type frequency in relapsing-remitting and secondary-progressive MS and evaluated whether detectability was correlated to the magnetization transfer ratio, an imaging marker sensitive to myelin content. Seven hundred and twenty total cortical lesions, 420 leukocortical lesions, 27 intracortical lesions, and 273 subpial lesions were cortical lesions count at 7T while 424 total cortical, 393 leukocortical, zero intracortical, and 31 subpial lesions were cortical lesion counts at 3T. Total, intracortical, and subpial 3T lesion counts were markedly lesser than the 7T counts. Leukocortical lesion counts did not significantly differ among scanners. Total and leukocortical lesion counts were markedly greater in secondary-progressive MS, at 3T and 7T. Subpial lesions were markedly greater in secondary-progressive MS at 7T. On both scanners, the magnetization transfer ratio values of leukocortical lesions visible were markedly lesser in comparison with the magnetization transfer ratio values of leukocortical lesions visible only at 3T. Between subpial lesions visible only at 7T and subpial lesions visible on both 3T and 7T, no meaningful variation was discovered in magnetization transfer ratio values. Hence, the detection of leukocortical lesions at 3T was analogous to that at 7T MR imaging. Imaging at 3T was concluded as less sensitive to intracortical and subpial lesions. Leukocortical lesions that were not apparent on 7T T2*-weighted MRI could be correlated with less demyelination as compared to those that were visible. Moreover, the detectability of subpial lesions didn't seem to be linked to the degree of demyelination.