Ye W, Liu Y, Liu WF, et al. - In this meta-analysis of a randomized controlled trial, the efficacy, and safety of oral and intravenous tranexamic acid were compared for primary total knee and hip arthroplasty. They searched the PubMed, Embase, and Cochrane Library databases for relevant studies published before June 20, 2019. Using a fixed-effects or random-effects model, they estimated weighted mean differences and relative risks. Researchers enrolled ten studies including a total of 1,140 (oral 557; intravenous 583) individuals. No significant difference was found in terms of total blood loss, the decline in hemoglobin, the length of hospital stay, the incidence of deep vein thrombosis or intramuscular venous thrombosis, or the transfusion rate between the oral and intravenous groups, and five studies described that oral tranexamic acid was correlated with a lower cost.