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Comparison of early surgical or transcatheter aortic valve replacement vs conservative management in low‐flow, low‐gradient aortic stenosis using inverse probability of treatment weighting: Results from the TOPAS prospective observational cohort study

Journal of the American Heart Association Dec 13, 2020

Annabi MS, Côté N, Dahou A, et al. - Among prospectively recruited 481 consecutive patients (75±10 years; 71% men) with low‐flow, low‐gradient (LFLG) aortic stenosis (AS) (aortic valve area ≤ 0.6 cm2/m2 and mean gradient < 40 mm Hg) in the multicenter TOPAS (True or Pseudo Severe Aortic Stenosis) study, researchers compared early (ie, ≤ 3 months) aortic valve replacement (AVR) vs conservative management or of transcatheter AVR (TAVR) vs surgical AVR. Among participants, 72% had classic LFLG and 28% had paradoxical LFLG. Deaths of 220 patients were reported during follow‐up (median [IQR] 36 [11–60] months). As per findings of this large prospective observational study, a major survival benefit seemed to be conferred by early AVR in both classic and paradoxical LFLG AS. This advantage appeared to extend to the subgroup with pseudo‐severe AS. These data indicate that the best strategy in these patients might be TAVR using femoral access.

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