Thongmee W, Narongkhananukul C, Padungkiatsagul T, et al. - Researchers conducted this retrospective study to compare demographic data, clinical and radiological features, treatments, and long-term visual outcomes between patients with late-onset neuromyelitis optica spectrum disorder-related optic neuritis (LO-NMOSD-ON) (age at onset ≥ 50 years) and patients with early-onset neuromyelitis optica spectrum disorder-related optic neuritis (EO-NMOSD-ON) (age at onset < 50 years). The sample consisted of 47 patients (69 eyes) who were diagnosed with neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) over a 12-year period. Compared with patients with EO-NMOSD-ON, patients with LO-NMOSD-ON had significantly worse nadir VA at ON onset and significantly worse final VA. Age at ON onset of each eye was positively associated with final VA (logMAR). NMOSD-ON should be included in the differential diagnosis of late-onset acute to subacute optic neuropathy, along with ischemic optic neuropathy, considering the disparity in common age at onset.