Ojji DB, et al. - Via performing a randomized, single-blind, three-group trial in six countries in sub-Saharan Africa that included 728 black patients with uncontrolled hypertension, researchers determined the effectiveness of the currently available two-drug combination for blood-pressure control, as the prevalence of hypertension among them is high, and these patients usually need two or more medications for blood-pressure control. Those who received amlodipine plus hydrochlorothiazide and those who received amlodipine plus perindopril had lower 24-hour ambulatory systolic blood pressure readings than those who received perindopril plus hydrochlorothiazide. However, similar differential effects on office and ambulatory diastolic blood pressures, along with blood-pressure control and response rates, among the three groups (amlodipine plus hydrochlorothiazide; amlodipine plus perindopril; perindopril plus hydrochlorothiazide) was noted. Thus, according to findings, amlodipine plus either hydrochlorothiazide or perindopril may be more effective than perindopril plus hydrochlorothiazide at lowering blood pressure levels at 6 months in this population of black patients in sub-Saharan Africa.